Duromine drug interactions



Duromine drug interactions mean a change of efficiency and safety of Duromine pharmacological effect on the human body in a concomitant or a subsequent use of this drug along with other drugs.

Clinically significant interactions are considered those that are caused by medications, affecting the safety and efficiency of the pharmacotherapy during anti-obesity treatment by means of Duromine psychostimulant.

Rational combination of drugs with Duromine weight loss pills involves such drug interactions that can increase the effectiveness and safety of the drug anti-obesity therapy.

However, not every Duromine drug interaction increases its therapeutic effect. More often, there are cases when other medications reduce the efficiency of Duromine pharmacotherapy. Such drug combinations are considered irrational.

The potentially dangerous combinations of amphetamine-derivative Duromine with other drugs can reduce the safety of Duromine anti-obesity therapy.

The potentially life-threatening drug interactions and their mutual influence on each other are a serious clinical problem these days. According to various data, about 17-23% of the prescribed combinations of Duromine and other drugs are dangerous for patients who use them.

Usually, drug interactions are divided onto pharmacological and pharmaceutical types. Pharmacological drug interactions are characterized by the change in pharmacokinetics and pharmacodynamics of medications, chemical and physic-chemical interactions of Duromine anorexigenic drug and other medications in the body environment.

Duromine pharmacokinetic drug interactions may develop on such levels as:

  • Absorption
  • Distribution
  • Biotransformation
  • Excretion

Duromine drug interactions on the absorption level involve the rate and degree of absorption of the active ingredients.

Thus, the change in the rate and degree of Duromine absorption has high clinical relevance. The changed absorption of the drug is also relevant when patients need to achieve a maximum effect of Duromine appetite suppressant.

The absorption degree of Duromine has always a great significance, since the drug absorption affects the ratio of the used dose of Duromine anti-obesity drug and its blood concentration.

The absorption of Duromine in the gastrointestinal tract can be changed depending on other drugs influence, if they interact with it on a chemical level or if they change the acidity of the stomach or intestines.

Medications, combined with Duromine can affect the time of passing of this anorexigenic drug along the gastrointestinal tract or flora of the digestive tract.

There are medications, inhibiting and stimulating the absorption of Duromine active ingredient. Thus, Duromine drug absorption is greatly reduced if its components are bound with other drug or become insoluble under its influence.

Duromine pharmaceutical drug interactions are associated with different drugs combinations. Often, such combinations are used to increase or combine the healing effect of Duromine anorectic and other drugs.

Herewith, when Duromine is combined with other drugs, it may cause adverse reaction, usually called drugs incompatibility.

The incompatibility of Duromine with other medications is manifested as a complete loss or change in the pharmacotherapeutic effect of Duromine anti-obesity drug.

It happens quite often that Duromine drug interactions cause toxic or side effects in a patient’s body. This happens when a doctor prescribes two or more drugs (pharmacological incompatibility) at the same time.

When used by mouth, Duromine anorectic drug is distributed by blood all over the body. Thus, the rate and degree of Duromine drug is greatly affected by magnitude of the blood flow, which in turn depends on the cardiac output and the blood vessels tone.

Medications influencing the cardiovascular system (cardiac glycosides, hypotensive, anti-arrhythmic and diuretic drugs) and those that are used along with Duromine, can affect the distribution of Duromine drug ingredients.

Therefore, such medications can also affect the intensity and duration of Duromine effect.

Duromine drug interactions on the biotransformation level are usually divided into two stages. On the first stage, this process forms metabolites possessing certain activity. On the second stage of biotransformation, the metabolites are transformed into water-soluble conjugates that are easily excreted from the body afterwards.

The biotransformation of Duromine drug is carried out under the influence of hepatic microsomal enzymes, which activity may change.

Many drugs can speed up the synthesis and increase the activity of enzymes that affect the chemical reactions rate during the transformation of Duromine drug.

When patient is taking Duromine in combination with other drugs, these drugs may serve as inducer of hepatic enzymes and can reduce the half-life of Duromine.

However, after the inducer withdrawal, the half-life of Duromine increases and the concentration of the drug reach or even exceed the initial levels.

The inducers of hepatic enzymes involve sleeping medicines (barbiturates, chloral hydrate), tranquilizers (Diazepam, chlordiazepoxide), neuroleptics (Aminazine), anticonvulsants (Difenin) and anti-inflammatory drugs (Butadion).

Different medications may interact with Duromine psychostimulant on an excretion level as well. Duromine is mostly excreted from the body by kidneys and bile.

Duromine drug interactions on the excretion stage may cause side effects. Typical side effects are dry mouth, dizziness, gastrointestinal disorders, anxiety and urticaria.

For a successful drug therapy, when using Duromine anti-obesity drug along with other medications, patients need to understand which pharmacodynamic and pharmacokinetic processes underlie the Duromine drug interactions.

The knowledge of rational, irrational and simply dangerous combinations of Duromine with other drugs will help to increase the effectiveness of Duromine therapy and minimize the side effects caused by other drugs.